This is a general problem related to item specifics. iSale integrates the available item specifics at the time we build the software, so they are stored within the application. If eBay changes something in between two versions of iSale, the older version will eventually send a deprecated combination of item specifics.
Unfortunately, fetching all item specifics each time you start the application or submit an auction would slow down iSale extremely, so we cannot eradicate this issue in general. It should not occur too often, though, because eBay usually applies only a few changes to item specifics.
There is a workaround, though:
This will force iSale to reload all item specifics
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